2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Cytochrome P450

Cytochrome P450

CYPs

Cytochrome P450

Related Products

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Cytochrome p450 comprises a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. Having been found in every class of organism, including Archaea, the p450 superfamily is believed to have originated from an ancestral gene that existed over 3 billion years ago. Repeated gene duplications have subsequently given rise to one of the largest of multigene families. These enzymes are notable both for the diversity of reactions that they catalyze and the range of chemically dissimilar substrates upon which they act. Cytochrome p450s support the oxidative, peroxidative and reductive metabolism of such endogenous and xenobiotic substrates as environmental pollutants, agrochemicals, plant allelochemicals, steroids, prostaglandins and fatty acids. In humans, Cytochrome p450s are best known for their central role in phase I drug metabolism where they are of critical importance to two of the most significant problems in clinical pharmacology: drug interactions and interindividual variability in drug metabolism.

Cytochrome P450 Isoform Specific Products:

Cytochrome P450 Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W087008
    7-Hydroxyflavanone
    		Inhibitor 99.59%
    7-Hydroxyflavanone is a potent inhibitor of aromatase (CYP19) activity with the IC50 of 65 μM. 7-Hydroxyflavanone exerts various biological effects, including anticarcinogenic, antioxidant and (anti-)estrogenic effects, and modula
    7-Hydroxyflavanone
  • HY-E70503
    Human CYP3A7,High-Reductase+b5
    Human CYP3A7, Low-Reductase+b5, a recombinant CYP3A7, a major fetal‐type P450 enzyme is mainly expressed in the human fetal liver and intestine.
    Human CYP3A7,High-Reductase+b5
  • HY-W762018
    2,3,4,6,7,8-Hexachlorodibenzofuran
    		Inducer
    2,3,4,6,7,8-Hexachlorodibenzofuran (2,3,4,6,7,8-HxCDF) is a dioxin-like polychlorinated dibenzofuran (PCDF). 2,3,4,6,7,8-Hexachlorodibenzofuran induces expression of the genes encoding aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin-O-deethylase (EROD) in H-4-II-E rat hepatoma cells (EC50s = 0.687 and 0.575 nM, respectively).
    2,3,4,6,7,8-Hexachlorodibenzofuran
  • HY-128920
    Phortress free base
    		Inhibitor
    Phortress free base (NSC 710305) is a P450 CYP1A1-activated antitumor prodrug with antitumor activity. Phortress free base leads to DNA damage and cell cycle arrest.
    Phortress free base
  • HY-158429
    PROTAC CYP1B1 degrader-2
    		Degrader
    PROTAC CYP1B1 degrader-2 (compound PV2) is a von Hippel-Landau (VHL) E3 ligase-based CYP1B1 degrader with the DC50 of 1.0 nM at 24 h in A549/Taxol cells. PROTAC CYP1B1 degrader-2 inhibits growth, migration, and invasion of A549/Taxol cell(Sturcture Note:(Blue: VHL ligand (HY-112078), Black: linker (HY-W007700), Pink: CYP1B1 ligand (HY-159006).
    PROTAC CYP1B1 degrader-2
  • HY-136589
    Verapamil EP Impurity C hydrochloride
    		Inhibitor 99.61%
    NSC-609249 hydrochloride is an impurity of Verapamil (HY-14275). Verapamil is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor.
    Verapamil EP Impurity C hydrochloride
  • HY-19435A
    GYKI-47261 dihydrochloride
    		Activator
    GYKI-47261 dihydrochloride is a competitive, orally active, and selective AMPA receptor antagonist with an IC50 of 2.5 μM. GYKI-47261 has broad spectrum anticonvulsive activity and neuroprotective effects. GYKI-47261 dihydrochloride is also a potent inducer of CYP2E1.
    GYKI-47261 dihydrochloride
  • HY-E70461
    Human CYP2D6,High-Reductase
    Human CYP2D6, High-Reductase, a recombinant CYP2D6, is a member of the CYP enzyme family. CYP2D6 plays important roles in the liver and in the brain with regards to xenobiotic metabolism.
    Human CYP2D6,High-Reductase
  • HY-155141
    hCYP3A4-IN-1
    		Inhibitor
    hCYP3A4-IN-1 (compound C6) is a potent, orally active hCYP3A4 inhibitor. hCYP3A4-IN-1 shows the IC50 values of 43.93 nM and 153.00 nM against hCYP3A4 in human liver microsomes (HLMs) and CHO-3A4 stably transfected cell line, respectively. hCYP3A4-IN-1 potently inhibits CYP3A4-catalyzed N-ethyl-1,8-naphthalimide (NEN) hydroxylation in a competitive manner (Ki = 30.00 nM).
    hCYP3A4-IN-1
  • HY-E70463
    Human CYP2E1,High-Reductase
    Human CYP2E1, High-Reductase, a recombinant CYP2E1, is a member of the CYP enzyme family and is involved in the metabolism of xenobiotics in the body.
    Human CYP2E1,High-Reductase
  • HY-E70484
    Human CYP2E1,High-Reductase+b5
    Human CYP2E1, High-Reductase+b5, a recombinant CYP2E1, is a member of the CYP enzyme family and is involved in the metabolism of xenobiotics in the body.
    Human CYP2E1,High-Reductase+b5
  • HY-157942
    CYP1B1-IN-7
    		Inhibitor 99.88%
    CYP1B1-IN-7 (compound 2a) is a selective inhibitor of CYP1B1 (IC50: 75 nM). CYP1B1-IN-7 also reverses resistance (IC50: 29 μM) and exhibits cytotoxicity in the CYP1B1-overexpressing MCF-7 cell line that is resistant to Docetaxel (HY-B0011).
    CYP1B1-IN-7
  • HY-144824
    Monoamine oxidase/Aromatase-IN-1
    		Inhibitor
    Monoamine oxidase/Aromatase-IN-1 (compound 2q) is a highly potent monoamine oxidase (MAO) and aromatase dual inhibitor with IC50s of 39 nM and 31 nM for MAO-B and aromatase, respectively. Monoamine oxidase/Aromatase-IN-1 can be used for researching neurological disorder and breast cancer.
    Monoamine oxidase/Aromatase-IN-1
  • HY-124364
    RO6889678
    		Activator
    RO6889678 is a highly potent HBV capsid formation inhibitor with a complex absorption, distribution, metabolism, and excretion (ADME) profile. RO6889678 is a potent inducer of CYP3A4 and coregulated proteins in human hepatocytes. RO6889678 is metabolized by a combination of CYP3A4-mediated oxidation and UDP-glucuronosyltransferase UGT1A3- and UGT1A1-mediated direct glucuronidation.
    RO6889678
  • HY-113986B
    (S)-Dexfadrostat
    		Inhibitor
    (S)-Dexfadrostat ((S)-Fadrozole) is an aromatase inhibitor with an IC50 of 4.6 nM in human placental microsomes in vitro. (S)-Dexfadrostat can be used in the study of estrogen-dependent breast cancer, gynecomastia, and systemic lupus erythematosus.
    (S)-Dexfadrostat
  • HY-149617
    CYP51/PD-L1-IN-4
    		Inhibitor
    CYP51/PD-L1-IN-4 (compound 14a-2) is a potent dual-target (CYP51/PD-L1) inhibitor, with IC50 values of 0.17 and 0.021 μM, respectively. CYP51/PD-L1-IN-4 exhibits excellent antifungal and antidrug-resistant fungal activity in vitro. CYP51/PD-L1-IN-4 can be used for fungal infections research.
    CYP51/PD-L1-IN-4
  • HY-E70512
    Human CYP17A1,High-Reductase+b5
    Human CYP17A1, High-Reductase+b5, a recombinant CYP17A1, is a member of the CYP enzyme family. CYP17A1 plays a crucial role in human steroid hormone synthesis.
    Human CYP17A1,High-Reductase+b5
  • HY-103540
    Tabimorelin hemifumarate
    		Inhibitor
    Tabimorelin (NN703) hemifumarate is an orally active growth hormone (GH) secretagogue. Tabimorelin hemifumarate is also a potent inhibitor of CYP3A4 activity.
    Tabimorelin hemifumarate
  • HY-W683681
    16α-Hydroxy etiocholanolone
    16α-Hydroxy etiocholanolone is a metabolite of 16a-Hydroxydehydroisoandrosterone (HY-113031).
    16α-Hydroxy etiocholanolone
  • HY-19435
    GYKI-47261
    		Activator
    GYKI-47261 is a competitive, orally active, and selective AMPA receptor antagonist with an IC50 of 2.5 μM. GYKI-47261 has broad spectrum anticonvulsive activity and neuroprotective effects. GYKI-47261 is also a potent inducer of CYP2E1.
    GYKI-47261
Cat. No. Product Name / Synonyms Application Reactivity
Cytochrome P450 Isoform Comparison

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